Therefore, these results cannot be generalised to the population as a whole. Vaccination with the main non-mRNA vaccine used in the UK was stopped for young people following safety concerns in April 2021, and most of the young people who received it would have been prioritised due to clinical vulnerability or being healthcare workers. However, receiving a first dose of a non-mRNA vaccine was associated with an increased risk of cardiac death in young women. ![]() “We find no evidence that the risk of cardiac or all cause death is increased in the weeks following vaccination with mRNA vaccines. Existing studies show that COVID-19 vaccination is linked to an increased risk of cardiac diseases. “Today’s analysis looks at the risk of death after COVID-19 vaccination in young people. It is important to consider the risks of vaccination in light of the benefits this analysis of vaccine safety contributes to the growing body of scientific work on the impact of vaccinations. We find no strong evidence of an increase in risk of cardiac or all-cause death after vaccination for young men for either vaccine type we will continue to monitor this as more deaths are registered and more doses are administered.Ī positive SARS-CoV-2 test was associated with increased cardiac and all-cause mortality among people the risk was higher in those who were unvaccinated at time of testing than in those who were vaccinated. ![]() The subgroup who received non-mRNA vaccines was more likely to be clinically vulnerable and may be at greater risk of adverse events following vaccination than the general population.Īccording to the statistical model, 11 out of the 15 cardiac deaths in young women that occurred within 12 weeks of a first dose of a non-mRNA vaccine were likely to be linked to the vaccine this corresponds to 6 cardiac-related deaths per 100,000 females vaccinated with at least a first dose of a non-mRNA vaccine. There was evidence of an increase in cardiac death in young women after a first dose of non-mRNA vaccines, with the risk being 3.5 times higher in the 12 weeks following vaccination, compared with the longer-term risk. There was no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared with more than 12 weeks after any dose for the study population as a whole. Several studies have reported associations between coronavirus (COVID-19) vaccination and risk of cardiac diseases, especially in young people we assessed the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (aged 12 to 29 years) in England using a self-controlled case series design.
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